Virus-Host Coevolution: Common Patterns of Nucleotide Motif Usage in Flaviviridae and Their Hosts (original) (raw)
Figure 5
Hierarchical clustering of Flaviviridae viruses and their hosts based on codon usage likeness.
RSCU values were calculated for codons with degeneracy greater than one for every organism, generating a matrix of N×M dimensions, being N the number of species and M the number of degenerated codons. Hierarchical clustering of organisms was conducted based on Spearman's rho correlation coefficients of RSCU values. Color schema for clusters is the same used in Figure 1. Flavivirus genus is highlighted in blue, Pestivirus is in green and Hepacivirus is in salmon. Flavivirus taxon was further divided according to host range: orange - insect-only, purple - NKV, yellow - mosquito-borne, red - tick-borne. Acronyms and names of viruses are defined in the “viral dataset” section.