Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2 (original) (raw)
Figure 8
Effect of S1-resistance on ligand-independent activation associated with T-ALL mutations of human Notch1.
U2OS cells were transiently transfected with ΔEGF receptors containing T-ALL associated mutations alone or in cis with the S1-resistant loop-deletion mutation (f-; for furin-resistant). All data points were obtained in triplicate, with error bars indicating the standard deviation of the three replicates.