Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease (original) (raw)
Figure 4
H2, but not Mg ion and alkalinity, protected the neuronal damage from acute MPTP neurotoxicity.
(A) TH-positive neurons in SN in mice drinking pure water (non-H2 water), Mg(OH)2 water or degassed H2/Mg water. Neither Mg(OH)2 water nor degassed H2/Mg water had significant effect on MPTP neurotoxicity. (B) Average number of TH-positive neurons in SNpc in mice drinking non-H2 water, Mg(OH)2 water, and degassed H2/Mg water. (C) The amount of MPP+ in striatum in mice drinking H2/Mg water (white) and pure water (black) was not significantly different. MPP+ was measured 3 h after the last MPTP administration, when the concentration of MPTP reached maximum. One-way ANOVA. Error bars represent mean ± SEM.