Characterization of Multiple Ion Channels in Cultured Human Cardiac Fibroblasts (original) (raw)
Figure 7
Kinetics of INa.TTX and INa.TTXR.
A. Mean values of I-V relationships of INa.TTX and INa.TTXR. B. Left panel: inactivation time course of representative INa traces (at 0 mV) was fitted to a monoexponential function with time constant (τ) shown, 4.3 ms for INa.TTX and 1.82 ms for INa.TTXR. Right panel: mean values of voltage dependence of inactivation of INa.TTX (n = 8) and INa.TTXR (n = 10). P<0.05 or P<0.01 at −20 to +60 mV. C. Voltage-dependent availability (I/Imax) of INa was determined with the protocol as shown in the left inset (with 1-s conditioning pulses from voltages between −120 and −10 mV then a 50-ms test pulse to 0 mV). Curves of I/Imax and activation conductance (g/gmax) were fitted to a Boltzmann equation. E. Recovery curves of INa.TTX and INa.TTXR from inactivation were fitted to a monoexponential function.