A New Paradigm for MAPK: Structural Interactions of hERK1 with Mitochondria in HeLa Cells (original) (raw)
Figure 8
Postulated structural interactions of hERK1 with mitochondria.
Scheme showing a new perspective for the physiological role of hERK1 in relation to the regulation of cellular signalling and trafficking in HeLa cells. ERK1 may be a carriage protein that would facilitate histone traffic to the ATP source in the surroundings of the OMM, and afterwards to the nuclei. Altogether this complex may interact with ERK transcription factors and the transcription machinery to enhance RNA synthesis. ERK translocation into and out the mitochondria may occur via VDAC protein. Once inside, the kinase may regulate mtDNA transcription by regulation of TFAM. I, II, III and IV: mitochondrial electron transport chain complexes, Cyt: cytochrome c, ANT: ATP carrier. The model is simplified for H2A, but the same is proposed for H4.