Proteomic and Phospho-Proteomic Profile of Human Platelets in Basal, Resting State: Insights into Integrin Signaling (original) (raw)
Figure 10
Platelet Protein-Protein Interaction (PPI) network.
A graph showing the platelet PPI network. Literature curated interactions between any set of two platelet were identified using the publicly available HPRD database [54] and graphed to generate a PPI network. Each platelet protein is shown as a colored dot and interaction between any two proteins is shown as a blue colored edge. Black dots represent phospho-proteins identified in this study. The PPI network was visualized using Cytoscape [55] and proteins showing high degree of interactions were clustered using the MCODE plugin [57]. Protein nodes that were found to be clustered based on degree of interactions are grouped and are shown in a single color. Biological function of protein clusters was determined using Uniprot database and is shown above.