Roles for the Conserved Spc105p/Kre28p Complex in Kinetochore-Microtubule Binding and the Spindle Assembly Checkpoint (original) (raw)
Figure 2
Kre28p, the candidate orthologue of metazoan Zwint-1, is essential for the viability of budding yeast.
(A) Protein sequence alignment (T-Coffee) of human Zwint-1 and Saccharomyces cerevisiae Kre28p. Residues labeled red are identical, residues labeled blue are similar. (B) KRE28 is essential for the viability of S. cerevisiae W303 as determined by gene complementation and tetrad analysis (see text for details).