Notch2 Signaling Sensitizes Endothelial Cells to Apoptosis by Negatively Regulating the Key Protective Molecule Survivin (original) (raw)
Figure 1
Regulation of Notch2 signaling in response to TNF.
(A) RT-PCR for Notch1-4 in ECs treated with TNF. A western blotting analysis (B) and its quantification showing the expression of the native Notch2 (C) and the activated cleaved form (cNotch2) in response to TNF (D). (E) RT-PCR for Notch2 and hey1 in ECs treated with TNF. (F) qRT-PCR for hey1 in EC stimulated with TNF and DAPT. *p<0.05 versus controls.