Reprogramming of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation in Generation of Pluripotent Stem Cells from Different Cell Types (original) (raw)
Figure 7
A model for regulation of 3′UTR by APA in proliferation/differentiation.
During proliferation, dedifferentiation, and cell transformation, high mRNA polyadenylation activity leads to usage of proximal poly(A) sites, whereas during differentiation, low mRNA polyadenylation activity leads to usage of distal poly(A) sites. The signs ‘+’ and ‘−’ indicate activation and inhibition, respectively.