Macrophage Plasticity in Experimental Atherosclerosis (original) (raw)
Figure 2
Kinetic expression of M1 and M2 markers.
Bone marrow-derived MØ from C57BL/6 mice (MØB6, closed circles) and ApoE KO mice (MØApoE, open circles) were differentiated, primed with IFNγ and polarized or not (No polarization) towards the M1 (M1 polarization) or the M2 phenotype (M2 polarization). Expression of Arg I, iNOS, Arg II were determined by real time PCR and normalized by HPRT (au: arbitrary unit). IL-6 was monitored in cell culture supernatant by ELISA. Results are representative of three independent experiments.