Macrophage Plasticity in Experimental Atherosclerosis (original) (raw)
Figure 4
ApoE modulates the expression of PPARγ.
A: Expression of IL-4Rα1 and of IL-13Rα1 in non-polarized MØB6 and MØApoE determined by real time PCR and normalized by HPRT (au: arbitrary unit). B: Expression of PPARγ in non-polarized MØ from MØB6 (black) and MØApoE (white) mice with increasing doses of recombinant ApoE (rApoE) determined by real time PCR and normalized by HPRT (au: arbitrary unit). **: p<0.001; ***: p<0.0001 vs MØB6. C: Expression of ArgI in M1 and M2 MØB6 (black) and MØApoE (white) mice polarized with or without (−) pioglitazone (Pio) or GW9662 (GW) determined by real time PCR. The Results are expressed as 2−ΔΔCt [30]. *: p<0.05; **: p<0.001 vs matched MØB6 condition; †: p<0.05; ††: p<0.01 vs matched M1 condition.