Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages (original) (raw)
Figure 4
Local and abbreviated SAP treatment significant reduces bleomycin-induced collagen generation and deposition.
Mice were challenged with intratracheal bleomycin (0.03 U) on day 0 and dosed with SAP (6 mg/kg) every other day on days 11–19 intraperitoneally (i.p., filled bar) or intranasally (i.n., down-hatched bar); or dosed with SAP (10 mg/kg, i.p.) on days 11,12,13 only (cross-hatched bar); or dosed with control (P5S, i.n., open bar) every other day on days 11–19. Collagen was quantitated biochemically (A) and visualized histologically (B). Original magnification, ×20. Bars represent the mean ± s.e.m. of a minimum of n = 5 per group. *_P_≤0.05 significance using Mann Whitney t-test.