A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype (original) (raw)
Figure 3
TLR3 activation inhibits bone and fat differentiation.
TLR4 activation promotes bone differentiation and inhibits fat differentiation in hMSCs. Methods: The hMSCs were induced (+) to differentiate in the presence of TLR3 and TLR4 ligands throughout the four-week incubation period prior to staining for differentiation markers by established methods. Untreated hMSCs (untx) were either induced (+) or not and served as assay controls. (n>3)