Tumor Tissue-Derived Formaldehyde and Acidic Microenvironment Synergistically Induce Bone Cancer Pain (original) (raw)
Figure 3
Capsaicin- or formaldehyde (100 µl/paw)-induced acute pain responses.
(A) Melatonin, capsazepine and AP-18 attenuated formaldehyde-induced pain responses. (B) Low pH enhanced formaldehyde-induced pain responses. (C) Melatonin (MT) and capsazepine (CPZ) blocked capsaicin (0.5 mM)-induced pain responses. (D) AP-18 did not block capsaicin-induced pain responses. Con: control; DMSO: vehicle; CAP: capsaicine. * _p<_0.05, ** _p<_0.01, ## _p<_0.01, & p<0.05, && p<0.01, all compared with respective controls. n = 10.