Mitochondrial Superoxide Contributes to Blood Flow and Axonal Transport Deficits in the Tg2576 Mouse Model of Alzheimer's Disease (original) (raw)
Figure 4
SOD-2 overexpression prevents increases in phospho-tau-ser262 in Tg2576 mice.
A) Graph represents quantification of the levels of phospho-tau-ser262 normalized to total tau from 12 to 16 months old olfactory bulb homogenates of WT, SOD-2, Tg2576 and Tg2576/SOD-2 mice. Significance was assessed by one way ANOVA with Dunnett's post-test for multiple comparisons. *p<0.05; **p<0.01. B) Representative Western blot of phospho-tau-Ser262, total tau and β-actin from olfactory bulb homogenates of 12 to 16 months old WT, SOD-2, Tg2576 and Tg2576/SOD-2 mice.