A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo (original) (raw)
Figure 8
Duration of action after a single i.v. injection in mice.
A single injection of 20 mg/kg LNA ASO generated a significant reduction of PCSK9 mRNA lasting for more than two weeks (A), with concomitant increase in LDLR protein (B). Levels were normalized at day 32. (Mean and SEM, n = 4–5).