Disrupted Functional Connectivity with Dopaminergic Midbrain in Cocaine Abusers (original) (raw)
Figure 2
Functional connectivity analysis of task-related signal fluctuations during the blocked fMRI paradigm.
A: BOLD response elicited by the drug-word paradigm (black curve) and the fitted SPM2 canonic hemodynamic response (red curve). The gray periods identify the plateaus of the model. B: “Word” time series are composed by 37 the time points of plateau 1 (green curve) and the 37 time points of plateau 2 (blue curve). C: Mid-sagittal slice of an MRI structure showing the position of the midbrain seed used for the functional connectivity analysis. D: Mid-saggital slice exemplifying the normalized (z-score) maps reflecting correlations of MRI signals in the brain with those in midbrain. These individual maps were used in group analyses of functional connectivity.