Disrupted Functional Connectivity with Dopaminergic Midbrain in Cocaine Abusers (original) (raw)
Figure 5
Brain activation and functional connectivity of midbrain.
A: Statistical map of BOLD-fMRI signals during the DW task across word conditions (conjunctive analysis “Drug” + “Neutral” vs. resting baseline) for controls > cocaine, superimposed on a sagittal view of the human brain. The light-blue squares and labels mark the positions of relevant ROI. The left side bar plots display the average BOLD responses in these regions for the cocaine and control groups (P<0.05). 5B: Statistical map of correlations with midbrain (CM) across word conditions (conjunctive analysis “Drug” + “Neutral” vs. resting baseline) for controls > cocaine, superimposed on a sagittal view of the human brain. The right side bar plots display the average CM signals in these regions for the cocaine and control groups (P<0.05). SPM Model: two-way repeated measures ANOVA. Sample: cocaine (N = 20) and control (N = 20) subjects. MDTHA: medial dorsal nucleus of the thalamus; CER: cerebellum (culmen); rACC: rostral anterior cingulate cortex (BA 32). ROI volume = 27 voxels (0.73 cc). Error bars are standard errors. CER: cerebellum; MDTHA: medial dorsal nucleus of the thalamus; rACC: rostral Anterior cingulate cortex.