Dendritic Cells in Chronic Mycobacterial Granulomas Restrict Local Anti-Bacterial T Cell Response in a Murine Model (original) (raw)
Figure 10
Changing role of dendritic cells in mycobacterium-induced granulomas over time.
Scheme showing the changing phenotype of granuloma DCs in the transition from acute to chronic infection. Acute lesions contain DCs with high MHCII, and T cell costimulatory molecule (MHCII, CD40, CD80/86) expression. As the infection becomes chronic, DCs within the granuloma have decreased expression of MHCII, activating costimulatory molecules, and increased expression of inhibitory molecules PD-L1 and PD-L2. Expression of these inhibitory molecules results in an inability of local CD11c+ cells to reactivate IFNγ-producing CD4+ T cells, and therefore, shielding the granuloma-located bacteria from an important anti-bacterial factor.