Single-Dose Mucosal Immunization with a Candidate Universal Influenza Vaccine Provides Rapid Protection from Virulent H5N1, H3N2 and H1N1 Viruses (original) (raw)
Figure 1
Single-dose i.n. rAd immunization protects from lethal influenza virus challenge.
Groups of ten 12-week old BALB/cAnNCr mice were immunized with 1×1010 particles of A/NP-rAd or M2-rAd, or with 1×1010 particles each of A/NP and M2-rAd, via the i.m. or i.n. routes. 4 weeks after immunization, animals were challenged i.n. with 104 TCID50 (100 LD50) A/FM/1/47-ma (H1N1) and monitored for survival (A) and weight loss (B).