Synaptic Defects in the Spinal and Neuromuscular Circuitry in a Mouse Model of Spinal Muscular Atrophy (original) (raw)
Figure 7
Proprioceptive sensory axons and neurons are reduced in SMNΔ7 mice.
(A) Sample pictures showing the cross section of lumbar 4 (L4) dorsal root axons from control and SMNΔ7 mice at P14. (B) Bar graph showing the average number of myelinated dorsal root axons in control (1707±20, n = 6) and SMNΔ7 mice (1577±27, n = 7), *p = 0.0032. (C) Micrographs showing proprioceptive neurons immuno-labeled with anti-parvalbumin (PV) antibody (in green) in the L4 dorsal root ganglion (DRG) of control and SMNΔ7 mice. (D) Bar graph of the total number of PV-positive cells in L4 DRGs in control (1138±27, n = 6) and SMNΔ7 (985±29, n = 4) mice, p<0.0001. Error bars show s.e.m.