Drug-Driven AMPA Receptor Redistribution Mimicked by Selective Dopamine Neuron Stimulation (original) (raw)
Figure 4
Expression of ChR2 causes light-activated currents in DA VTA neurons.
(A) Representative whole cell voltage clamp recordings of a DA VTA neuron. Following identification of cell type by the presence of an _I_h current (left) responses to light pulses (black lines) at 4 ms (middle) or 100 ms (right) in the presence of TTX were tested (n = 10). (B) Same as in (A) but a representative non-DA VTA neuron (note lack of _I_h (left); n = 6). (C) Digital micrograph showing YFP labeling of neurons within the VTA, together with putative GABAergic unlabeled neurons (asterisks).