Hypoxia Selects Bortezomib-Resistant Stem Cells of Chronic Myeloid Leukemia (original) (raw)
Figure 6
Effects of BZ on hypoxia-resistant primary CML cells.
Immunomagnetically-selected CD34+ bone marrow cells from 3 blast-crisis CML patients were treated in hypoxic LC1 (established at 3×104 viable cells/ml) as indicated (A) and transferred at day 7 into normoxic LC2 (3×104 viable cells/ml) (B), where trypan blue-negative cells were counted at the indicated times of incubation. Values represent means±S.E.M. of data from 3 independent experiments.