Characterization of the Contradictory Chromatin Signatures at the 3′ Exons of Zinc Finger Genes (original) (raw)
Figure 1
ZNF 3′ ends are not enriched for promoter motifs or CAGE tags.
(A) The 3′ ends of the ZNFs bound by H3K9me3, as well as a 1kb region centered on the start site (promoter) and a 1 kb region located 10 kb upstream (enhancer) of the same genes were searched in forward and reverse orientations for the sequence of nine motifs previously found to be enriched in promoter regions [16]. Since the sizes of the H3K9me3 regions varied from site to site, the data was normalized such that the motif counts are reported as the number of motifs found per 1000 base pairs. (B) The number of CAGE tags corresponding to the regions of the 3′ ends of the ZNFs bound by H3K9me3, as well as a 1 kb region centered on the start site (promoter) and a 1 kb region located 10 kb upstream (enhancer) of the same genes was determined; the data was normalized as described in Figure 1A.