Endocytosis Regulates Cell Soma Translocation and the Distribution of Adhesion Proteins in Migrating Neurons (original) (raw)
Figure 8
Model of Neuronal Migration.
A proposed model of neuronal migration consistent with our findings, though future work should address adhesion dynamics directly. Neurons first extend an exploratory leading process that forms transient and dynamic adhesions (perforated blue lines) in the growth cone. The leading process pauses, strengthening adhesions (solid blue lines) to provide traction. A cytoplasmic dilation forms, where endocytosis (gray circles) weakens adhesion. Myosin II (yellow) mediated contractions at the rear squeeze the nucleus forward and disrupt remaining attachments. Nucleokinesis into the former dilation establishes a new cell rear.