Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2 (original) (raw)
Figure 5
Behavioral analysis of LRRK2 transgenic mice.
A–D, In the open field G2019S LRRK2 TG mice (line 340) exhibit normal horizontal (A) and vertical (B) locomotor activity compared to NTG littermates at 6 and 15 months (n = 7–9 mice/genotype). R1441C LRRK2 TG mice (line 574) reveal normal locomotor activity at 6 months but deficits at 15 months (C and D) compared to NTG mice (n = 6-9 mice/genotype). Data represent the number of beam breaks during the first 15 min period. E–F, Normal pre-pulse inhibition (PPI) of the acoustic startle response in LRRK2 transgenic mice. E and F, G2019S and R1441C LRRK2 TG mice display normal PPI of the acoustic startle reflex at 15 months compared to their NTG littermates, with increasing pre-pulse tones of 74–90 dB (n = 6–8 mice/genotype). Data are expressed as % PPI relative to no pre-pulse tone. Bars present the mean ± SEM. *P<0.05 comparing TG with NTG as indicated.