The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study (original) (raw)
Figure 1
Summary of results.
The results for individual populations are presented here each population on its own line. For each population we report the allele frequency in MS patients (F MS) and controls (F ctrl), Hardy-Weinberg (dis)equilibrium (HWE) p value, odds ratio (OR) and association p value. The association analyses were performed according to Kazeem and Farral [15]. The reported HWE p value is reported for cases and controls combined, but no significant deviation was observed within cases or controls when analyzed separately (data not shown). Figure 1a represents the results for rs17824933 in CD6. The Replication -line is the combined result of all independent sample sets in the replication (8,047 cases, 9,174 controls, 604 case-parent trios) and “Combined with De Jager et al. GWA” set includes the De Jager et al. [11] GWA data set (2,624 cases, 7,220 controls). Figure 1b summaries the results for rs1800693 in TNFRSF1A. Genotyping was unsuccessful in two sample sets (Danish case – control set and French case-parent trios) for rs1800693. Indipendent replication data set (“Replication”) included total of 7,665 cases and 8,051 controls and the “Combined with De Jager et al. GWA” set includes available genotypes from De Jager et al. [11] (1,829 cases, 2,591 controls). Figure 1c is a summary of results for rs17445836 (61.5 kb from IRF8). The genotyping was unsuccessful in two sample sets (Spanish and German case – control sets). The independent replication set (Replication) includes in total 6,895 cases, 7,580 controls and 596 case-parent trios and the “Combined with De Jager et al. GWA” set includes available genotypes from De Jager et al. [11] (2,624 cases, 7,220 controls).