Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance (original) (raw)
Figure 7
Proposed model for mode of action of the polymorphisms found.
The central assumption is that ART, LUM and MQ drugs have their main pharmacological targets located in the cytoplasmic compartment while PfMRP1, operates by reducing the intra-cytoplasmatic concentrations by effluxing them out of the cell. Pgh-1, on its turn will contribute to further drug expulsion from the cytoplasm by transporting these drugs towards the lumen of the food vacuole.