IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke (original) (raw)
Figure 5
Requirement of IL-17RA for smoke induced lung inflammation.
(A) BAL levels of IL-17 after six months of cigarette smoke exposure (n = 5–6 per group, * denotes p<0.05 compared to WT sham). (B) BAL total cells and alveolar macrophage numbers after 6 months of smoke exposure. (n = 5–6 per group, * denotes p<0.05 compared to WT sham) (C) Levels of CCL2, CCL5, CXCL10 and CXCL1 in lung homogenate after six months of cigarette smoke exposure (n-5–6 per group, * denotes p<0.05 compared to WT sham). (D) Expression of transcripts for MMP12 and MMP9 using RT2 Profiler PCR Array. The delta Ct values were calculated by individual gene Ct value minus that of the associated housekeeping gene and expressed as relative gene expression compared to the WT sham group (n-5–6 per group, * denotes p<0.05 compared to WT sham).