Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse (original) (raw)
Figure 6
Mouse adaptive mutations on the primary structural maps of HA, NA, M1, M2, NS1 and NEP proteins.
Mutations are shown as indicated for Figure 3. The locations of protein binding and active sites are indicated; RNP ribonucleocapsid protein; NLS nuclear localization signal; NES nuclear export signal; dsRNA double-stranded RNA (aa 1–73); PABPI poly-A binding protein 1; PABPII poly-A binding protein II; RIG-I retinoic acid inducible gene I; E1B-AP5, E1B associated protein 5; CPSF cleavage and polyadenylation specificity factor; eIF4GI eukaryotic initiation factor 4GI; and PKR protein kinase R. The following mutations were mapped previously: HA1 G218W, HA2 T156N, NA P468H, M1 D232N, NS1 F103L + V23A, NEP K88R [59].