Comparative Analysis of mRNA Isoform Expression in Cardiac Hypertrophy and Development Reveals Multiple Post-Transcriptional Regulatory Modules (original) (raw)
Figure 6
Analysis of expression of miRNA target genes.
(A) Heatmap of miRNAs whose target genes were significantly regulated in hypertrophy (FDR<0.05). The color represents p-value which was calculated by comparison of CDF curves (see Materials and Methods for detail). The p-values for development datasets were also shown for comparison. miRNAs are sorted by their significance in 1 W TAC. (B) Expression changes of the genes targeted by miR-29 and miR-1. CDF curves of standardized log2(ratio) values are shown for ED, PD, and 1 W TAC samples. ED and PD are based on averaged values across ED and PD samples, respectively. 1 W TAC is based on averaged values of three samples (LVH1–3). P-values indicating difference between CDFs of miRNA target genes and other genes were derived from the Kolmogorov–Smirnov test.