Interleukin-6 Contributes to Inflammation and Remodeling in a Model of Adenosine Mediated Lung Injury (original) (raw)
Figure 2
Pulmonary inflammation following the treatment of _Ada_-/- mice with IL-6 neutralizing antibodies.
Mice were given subcutaneous injections of anti-IL-6 antibodies (30 mg/kg) as described in the methods. (A) Lungs from postnatal day 43 Ada+ mice treated with IL-6 antibody (left), treatment with the isotype antibody or vehicle PBS revealed no effect, _Ada_-/- mice treated with the isotype antibody (middle) or Anti-IL-6 (right). Images are representative of 11 animals from each group. Scale bars = 200 µm. (B) Total BAL inflammatory cells numbers. Cellular differentials for (C) macrophages, (D) lymphocytes, eosinophils, and neutrophils. Data are presented as mean cell counts ±SEM, n≥11. *, p≤0.05 Ada+ vs _Ada_-/- and #, p≤0.05 _Ada_-/- vs _Ada_-/- + Anti-IL-6.