Impaired Structural Motor Connectome in Amyotrophic Lateral Sclerosis (original) (raw)
Figure 2
Cortical brain regions with impaired structural connectivity in ALS.
(a) The NBS procedure revealed a sub-network of brain regions showing significantly reduced structural connectivity in ALS patients, compared to the healthy controls. Figure shows the set of involved parcellated cortical regions (p = 0.0075, see materials and methods). (b) Using an NBS threshold of p = 1/N (N being the number of nodes of the network), a similar but more extended network was revealed. This model-free approach revealed a sub-network consistent with known motor regions, including precentral and paracentral gyri (primary motor), caudal middle frontal and superior frontal gyri (supplemental motor areas, BA6). The subcortical structures found with the NBS procedure were not included in this figure. Right = Right; Left = Left.