Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (original) (raw)
Figure 4
Impaired CREB phosphorylation and hyper-phorsphorylation of GluR1 in Cdk5f/f/T29 mice.
A–B. Immunostaining (A) and quantification (B) of pCREB in hippocampal CA1 and cortex. Scale bar = 100 µm. C. Western blots of micro-dissected CA1 tissue show reduced pCREB levels. D. Western blots of micro-dissected CA1 tissue reveals hyper-phosphorylation of GluR1. E. Area CA1 phosphatase activity in Cdk5f/f and Cdk5f/f/T29 mice (n = 3, each group). *p<0.05, **p<0.005, ***p<0.001.