Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (original) (raw)
Figure 5
Proteomic analysis of post-synaptic densities reveals changes in PDE proteins in CDK5 mutant mice.
A. Procedure sequence for mass-spectrometry analysis with PSDs from control (Cdk5f/f) and Cdk5f/f/CW2 (cKO) mice. B. Summary of detected protein abundance differences categorized by various protein functions. C. Representative molecules changes detected in Cdk5 cKO mice. Red number indicates reduction folds; black number indicates increase folds. D. RT-qPCR results of ACs in hippocampal CA1 in Cdk5f/f and Cdk5f/f/T29. qPCR signals were normalized to actin in each sample (n = 3). E. RT-qPCR results of PDEs from hippocampal area CA1 in Cdk5f/f and Cdk5f/f/T29.