H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination (original) (raw)
Figure 3
Clonal lineage 2569 from EI13.
Three of 4 members (75%) derived from IgM-expressing plasma cells, 1/4 (25%) derived from an IgA1 plasma cell. The highest affinity binding for all members was to H3 Jobg; high affinity binding to other H3 rHAs and H1 Bris was also observed. Three members were tested for HAI and neutralization and displayed similar breadth (Table 3). H1 SI = H1N1 A/Solomon Islands/03/2006; H1 Bris = H1N1 A/Brisbane/59/2007; H1 Cal = H1N1 A/California/04/2009; H3 Wisc = H3N2 A/Wisconsin/67/2005; H3 Bris = H3N2 A/Brisbane/10/2007; H3 Jobg = H3N2 A/Johannesburg/33/1994; H5 Indo = H5N1 A/Indonesia/05/2005; H5 Viet = H5N1 A/Vietnam/1203/2004.