Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits (original) (raw)
Figure 3
Myelination patterns suggest largely normal late development but with periventricular disruption in Csf1r−/− mice.
Coronal sections from three week old wild type (A,C,E,G,I) and Csf1r−/− (B,D,F,H,J) mouse brain taken from equivalent co-ordinates along the rostrocaudal axis and immunostained for myelin basic protein (MBP) by immunoperoxidase (brown) and Hematoxylin counterstained (blue). Abbreviations: amygdale (a); alveus hippocampus (ah); cerebral cortex (c); corpus callosum (cc); cerebral peduncle (cp); dorsal hippocampal commissure (dhc); external capsule (ec); hippocampus (h); internal capsule (ic); lateral ventricle (lv); posterior commissure (pc); striatum (s); thalamus (t). (Section in H torn centrally during processing.) Scale bars A–F = 500 µm G–J = 200 µm.