FGF/FGFR Signaling Coordinates Skull Development by Modulating Magnitude of Morphological Integration: Evidence from Apert Syndrome Mouse Models (original) (raw)
Figure 3
PLS analyses among each Apert syndrome mouse model and their non-mutant littermates after removing allometry.
A) Fgfr2+/S252W and non-mutant littermates; B) Fgfr2+/P253R and non-mutant littermates. Associated facial and neurocranial shape changes corresponding to the first pair of PLS1 axes show similar skull MI patterns between the two models. Orange wireframes display face and neurocranium shape changes associated with positive and negative values of PLS1 in comparison to mean shape PLS1 values (grey dashed wireframe). For anatomical correspondence see Fig. 1. Note that all landmarks cannot be seen from a single skull view and we chose to display the inferior view of the skull because main shape changes occur in the palate and the anterior aspect of the neurocranium.