Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse (original) (raw)
Figure 1
Body weight and left ventricular mass in IL-1R1-/- and IL-1Ra-/- mice.
Genetically modified mice (both IL-1R1-/- and IL-1Ra-/- ) have significantly smaller body weights compared with the respective wild-type animals (WT). Left ventricular (LV) mass calculated at echocardiography was not statistically different comparing IL-1R1-/- and IL-1Ra-/- and respectively WT, but the IL-1R1-/- had significantly greater LV mass/weight ratio. N = 8–10 per group.