Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse (original) (raw)
Figure 4
Indirect comparison between the IL-1R1-/- and the IL-1Ra-/-.
Considering that IL-1R1-/- and the IL-1Ra-/- mice were generated in different backgrounds, a direct comparison between the 2 strains cannot be made. The Figure shows an indirect comparison between the 2 strains in which the value of each strain is normalized to the corresponding wild-type mouse. In the comparison, the IL-1R1-/- mouse shows to have smaller infarcts, less apoptosis and more favorable remodeling, wheras the IL-1Ra-/- mouse shows large infarcts, more apoptosis, and more unfavorable remodeling.