Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing (original) (raw)
Figure 6
Impairment of memory by 4-CIN injections, used to block MCT2.
The impairment was not reversed by either lactate or glucose. Blockade of the MCT-2 with 4-CIN impaired working memory in a dose-dependent manner (n = 6; Percent Alternation ± SEM: 1% DMSO in Saline = 65.2%±4.9% vs. 10 pmol 4-CIN = 47.4%±4.7%, p<0.05 and 30 pmol 4-CIN = 39.8%±3.3%, p<0.05). This impairment was not significantly reversed with the addition of either lactate or glucose (ps>0.1).