LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease (original) (raw)
Figure 4
Parameters of apoptosis.
(A) Scoring of TUNEL stained liver sections for apoptosis after chow and 3 months of HFC diet in C57Bl6, APOE2ki and Ldlr−/− mice. (B) Caspase 3/7 activity in liver homogenates. (C–G) Gene expression analysis of the apoptotic genes Bax, Bcl-2, Traf1, Bfl1 and Chop. (H) Aminotransferase (ALT) levels in plasma. Data were set relative to the C57Bl6 mice on the chow diet. * Significantly different from chow group. *, ** and *** indicate p<0.05, 0.01 and 0.001, respectively.