Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism (original) (raw)
Figure 2
Representative reconstructions of striatal MSN in week 13 and 16 mice.
Mice were exposed on day 0, 3, 6 with vehicle or MnCl2-4H2O (50 mg/kg s.c.), sacrificed on experimental day 7 (week 13, n = 4–5) or 28 (week 16, n = 5) and the striatum was processed for Golgi impregnation. Neurons were traced and analyzed using Neurolucida and Neuroexplorer, respectively (NeuroBrightField, Inc). Representative neurons shown were selected to be within 5% of the mean total dendritic length of each exposure group.