Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism (original) (raw)
Figure 3
YAC128-Mn exposed mice have decreased branching complexity at 16 weeks.
Morphological characteristics of MSNs were assessed using the Sholl method. Concentric rings at 10 µm intervals were centered at the soma and intersections of dendrites at each radius were counted to determine branching complexity. A) Dendritic branching complexity is not significantly different between groups at 13 weeks. B) Main effects of distance×genotype and distance×genotype×exposure for dendritic branching complexity were observed only at 16 weeks. C) Dendrite length as a function of distance from the soma is unaltered at 13 weeks. D) At 16 weeks, dendrite length as a function of distance from the soma is subject to distance×genotype and distance×genotype×exposure effects.