Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism (original) (raw)
Figure 5
Striatal DA and metabolites are affected at week 16 by Mn exposure and genotype.
A) There are no significant differences in striatal DA levels at week 13. B) There is no difference between striatal levels of DOPAC or HVA at week 13, however there is a significant main effect of genotype on ratio DOPAC/DA. The turnover rate of DA is significantly lower in YAC128-Mn than WT-Mn. C) At week 16 there is a significant effect of genotype and exposure on striatal DA levels. WT-Mn, YAC128-Veh and YAC128-Mn have lower levels of striatal DA than WT-Veh mice. D) There are also significant genotype and exposure effects on DA metabolites DOPAC and HVA at week 16. Levels of striatal DOPAC and HVA in WT-Mn, YAC128-Veh and YAC128-Mn are significantly lower than in WT-Veh mice. Monoamine neurotransmitter and metabolite means (week 13 n = 4–6 and week 16 n = 3–8) are graphed +/−SEM. Significance by post-hoc t-test *p<0.05, **p<0.01 and ##p<0.005.