Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered Inflammatory Phenotype (original) (raw)
Figure 2
Lithium treatment reduces the levels of abnormally phosphorylated tau protein in APPSwDI/NOS2−/− mice.
Panel A shows representative Western blot images for AT8, AT180 and ß-actin for APPSwDI/NOS2−/− mice receiving either lithium diet (L) or control diet (C). Panel B shows the relative quantification of the band intensity for AT8 and AT180 normalized to the ß-actin band. N = 11 lithium treated mice, N = 8 control treated mice. ** indicates P<0.01 when compared to control treated mice. Panels C and D show immunocytochemistry for AT8 in the frontal cortex region of APPSwDI/NOS2-/mice receiving control diet (C) or lithium supplemented diet (D) for 8 months. Scale bar in D for C and D = 50 µm.