Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon (original) (raw)
Figure 1
DSS induces colitis.
(A) Mouse body weight changes during DSS treatment compared to that of control animals (drinking water). C57BL/6 mice were exposed to 3% (w/v) DSS in the drinking water for the indicated numbers of days. Body weight changes are shown as means±SEMs. * P<0.05, ** P<0.01. (B) Hematoxylin-stained colonic sections of mice treated with DSS; the mice were sacrificed on day 8. (C) Associated histological scores. *** P<0.001. (D) Macroscopic inflammation was assessed using a mouse colonoscope. Photographs were obtained on the day of sacrifice and (E) an endoscopic score was calculated. *** P<0.001. (F) KC mRNA expression was measured in test and control animals. *** P<0.001. (G) Determination of MPO enzymatic activity as an index of neutrophil infiltration into injured tissue. Results are expressed as MPO –fold increases compared to those of control mice and represent means±SEMs of three independent determinations. *** P<0.01.