Fusion of the Mycobacterium tuberculosis Antigen 85A to an Oligomerization Domain Enhances Its Immunogenicity in Both Mice and Non-Human Primates (original) (raw)
Figure 6
T cell responses in the draining auricular draining lymph node three days after vaccination with 106 PFU MVA-Ag85A.
Graphs represent the frequency of IFN-γ+ CD4+ T cells (A) or CD8+ T cells (B) after 6 hours of restimulation with the total antigen 85A peptide pool and staining for a variety of surface activation markers (S4). Data were log transformed and analyzed with a 2-way analysis of variance; a significant effect of IMX313 fusion was only observed for the frequency of antigen 85A specific cells p = 0.0101 but not for any surface marker (Figure S3).