Pharmacokinetic Modeling of an Induction Regimen for In Vivo Combined Testing of Novel Drugs against Pediatric Acute Lymphoblastic Leukemia Xenografts (original) (raw)
Figure 2
In vivo sensitivity of ALL-19 to low dose VCR, DEX and ASP.
Female mice were engrafted with ALL-19 cells and treated with vehicle (A); DEX (5 mg/kg) (B); VCR (0.15 mg/kg) (C); and ASP (1000 U/kg) (D); as single agents or the combination of the three drugs at the same doses (VXL) (E). The %huCD45+ cells in PB of individual mice (A–E); control vehicle-treated mice (dashed lines); drug-treated mice (solid lines). Kaplan-Meier analysis of EFS (F) control (grey solid line), VCR (grey dashed line), DEX (black dashed line), ASP (black dotted line), VXL (solid black line). All events were leukaemia-related. Shaded boxes represent the treatment period.