Mechanism of Chemical Activation of Nrf2 (original) (raw)
Figure 1
CPDT and SF stimulate Nrf2 transactivation activity by stabilizing its protein.
(A) Chemical structure of CPDT and SF. RT-4 cells and NBT-II cells were treated with CPDT (50 µM), SF (8 µM) or vehicle (0.1% DMSO) for 6 or 24 h. (B) Whole cell lysates were then prepared for IB or (C) total RNA was isolated for RT-PCR analysis. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was used as a control.